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1.
Surg Obes Relat Dis ; 13(4): 637-642, 2017 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-27866751

RESUMO

BACKGROUND: Several longitudinal studies have explored the association of obesity and weight gain with periodontal disease. However, the effect of weight loss on periodontal tissues remains unclear. OBJECTIVE: To explore whether weight loss after bariatric surgery was associated with changes in periodontal measures over 12 months. SETTING: Two public hospitals in São Paulo, Brazil. METHODS: We used data from 110 morbidly obese patients (body mass index [BMI]>40 kg/m2 or≥35 kg/m2 with co-morbid conditions) who underwent bariatric surgery between April 2011 and March 2013. Data on demographic factors, BMI, smoking habits, and glucose levels were extracted from medical records preoperatively and after 6 and 12 months postsurgery. A full-mouth periodontal examination was conducted by trained examiners to assess probing pocket depth, clinical attachment loss, and bleeding on probing (BOP) at baseline and 6 and 12 months after surgery. Data were analyzed using linear mixed-effects models. RESULTS: BMI was not significantly related to the proportion of sites with BOP at baseline, but it was negatively associated with the rate of change in the proportion of sites with BOP. The greater the BMI loss, the higher the proportion of sites with BOP, particularly 6 months after surgery. However, BMI was not associated with baseline probing pocket depth and clinical attachment loss or rates of changes in these periodontal outcomes. CONCLUSION: The findings suggest that weight loss was associated with increased gingival bleeding, showing a peak at 6 months after bariatric surgery. Periodontal pocketing and attachment loss remained unchanged during the study period.


Assuntos
Cirurgia Bariátrica/efeitos adversos , Índice de Massa Corporal , Obesidade Mórbida/cirurgia , Doenças Periodontais/diagnóstico , Redução de Peso/fisiologia , Adulto , Brasil/epidemiologia , Progressão da Doença , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Obesidade Mórbida/complicações , Obesidade Mórbida/epidemiologia , Doenças Periodontais/complicações , Doenças Periodontais/epidemiologia , Prevalência , Estudos Prospectivos , Fatores de Tempo , Adulto Jovem
2.
PLoS One ; 11(10): e0164084, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27695053

RESUMO

Society has changed its own lifestyle, specially its eating habits and physical activities, leading to excessive weight and a sedentary behavior, which has contributed to obesity increase. Bariatric surgery is the most effective treatment to obesity, allowing weight loss and its maintenance. However, it has been related high levels of iron deficiency after surgery. A person's nutritional status might be affected by total or partial tooth loss. The aim of this longitudinal prospective cohort study was to evaluate the levels of serum ferritin before and after bariatric surgery and to identify if there is a relation with tooth loss. The sample was composed of 50 patients selected and assisted at Amaral Carvalho Hospital, located in Jaú city, Brazil. The use and necessity of prosthesis, dental absence or presence, and serum ferritin dosage were evaluated. Student's t test, Univariate analysis, Chi-square and Odds Ratio were adopted (p<0.05). There was no significant difference regarding the serum ferritin levels between dentate and edentulous patients prior to surgery (p = 0.436). After surgery, the serum ferritin levels were higher in edentulous patients (prosthesis users) when compared to the pre-surgical levels, and the post-surgical levels presented significant difference regarding the dentate patients (p = 0.024). It can be concluded that rehabilitated patients in postoperative period showed better levels of serum ferritin after surgical intervention.


Assuntos
Cirurgia Bariátrica , Ferritinas/sangue , Cirurgia Bariátrica/efeitos adversos , Feminino , Humanos , Masculino , Boca Edêntula , Obesidade/sangue , Obesidade/cirurgia , Período Perioperatório
3.
Rev Col Bras Cir ; 43(2): 136-8, 2016.
Artigo em Inglês, Português | MEDLINE | ID: mdl-27275596

RESUMO

Nutritional and metabolic complications can develop after Roux-en-Y gastric bypass (RYGB) when there is an exaggerated response to the anatomical and functional changes or when there is inadequate nutritional supplementation. Severe malnutrition is rare, but deficiencies of vitamin B12, iron, calcium and thiamin, metabolic bone disease and gallstones are common after RYGB. Shortage of vitamin B12, iron, calcium and also cholelithiasis are caused at least partially by excluding the duodenum and proximal jejunum from food transit. We designed a new procedure, with the maintenance of the duodenum and proximal jejunum in the gastrointestinal transit through interposition of jejunal loop, as a primary operation to prevent such deficiencies or as corrective surgery for severe malnutrition after RYGB with failure in responding to conservative treatment. Complicações nutricionais e metabólicas podem se desenvolver após a derivação gástrica em Y de Roux (DGYR) quando há uma resposta exagerada às mudanças anatômicas e funcionais ou quando há suplementação nutricional inadequada. A desnutrição grave é rara, mas deficiências de vitamina B12, ferro, cálcio e tiamina, doença óssea metabólica e cálculos biliares são comuns após a DGYR. Dessas deficiências mencionadas, a de vitamina B12, de ferro, de cálcio e também a colelitíase, são causadas, ao menos parcialmente, pela exclusão do duodeno e jejuno proximal. Um novo procedimento com a manutenção do duodeno e do jejuno proximal no trânsito gastrointestinal, mediante interposição de alça jejunal, foi idealizado como operação primária para prevenir essas deficiências ou como cirurgia corretiva de desnutrição grave após DGYR com falha na resposta a exaustivas tentativas de tratamento conservador.


Assuntos
Duodeno , Derivação Gástrica/métodos , Desnutrição/prevenção & controle , Desnutrição/cirurgia , Obesidade Mórbida/cirurgia , Complicações Pós-Operatórias/prevenção & controle , Humanos , Jejuno
4.
Surg Obes Relat Dis ; 12(2): e21-3, 2016 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-26775048

RESUMO

Roux-en-Y gastric bypass (RYGB) may result in nutritional deficiencies, mainly involving micronutrients, and occasionally protein-calorie malnutrition (PCM) because of the resulting anatomic and functional changes. Failure of conservative PCM treatment may be an indication for corrective surgery, where the technique may vary according to the surgical cause of the malnutrition. In this study, we present the results of the reconnection of the duodenum and the proximal jejunum to the alimentary tract for the treatment of severe PCM caused by malabsorption after RYGB.


Assuntos
Duodeno/cirurgia , Derivação Gástrica/efeitos adversos , Jejuno/cirurgia , Obesidade Mórbida/cirurgia , Procedimentos de Cirurgia Plástica/métodos , Complicações Pós-Operatórias/cirurgia , Desnutrição Proteico-Calórica/cirurgia , Anastomose Cirúrgica , Feminino , Humanos , Pessoa de Meia-Idade , Complicações Pós-Operatórias/etiologia , Desnutrição Proteico-Calórica/etiologia , Reoperação
6.
PLoS One ; 10(7): e0129687, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26177268

RESUMO

The aim of this study was to identify the impact of oral disease on the quality of life of morbid obese and normal weight individuals. Cohort was composed of 100 morbid-obese and 50 normal-weight subjects. Dental caries, community periodontal index, gingival bleeding on probing (BOP), calculus, probing pocket depth, clinical attachment level, dental wear, stimulated salivary flow, and salivary pH were used to evaluate oral diseases. Socioeconomic and the oral impacts on daily performances (OIDP) questionnaires showed the quality of life in both groups. Unpaired Student, Fisher's Exact, Chi-Square, Mann-Whitney, and Multiple Regression tests were used (p<0.05). Obese showed lower socio-economic level than control group, but no differences were found considering OIDP. No significant differences were observed between groups considering the number of absent teeth, bruxism, difficult mastication, calculus, initial caries lesion, and caries. However, saliva flow was low, and the salivary pH was changed in the obese group. Enamel wear was lower and dentine wear was higher in obese. More BOP, insertion loss, and periodontal pocket, especially the deeper ones, were found in obese subjects. The regression model showed gender, smoking, salivary pH, socio-economic level, periodontal pocket, and periodontal insertion loss significantly associated to obesity. However, both OIDP and BOP did not show significant contribution to the model. The quality of life of morbid obese was more negatively influenced by oral disease and socio-economic factors than in normal weight subjects.


Assuntos
Peso Corporal , Obesidade Mórbida/complicações , Saúde Bucal , Qualidade de Vida , Adulto , Estudos de Casos e Controles , Estudos Transversais , Feminino , Humanos , Masculino , Obesidade Mórbida/epidemiologia
7.
J Clin Periodontol ; 42(6): 530-6, 2015 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-25924695

RESUMO

AIM: The aim this study was to evaluate the influence of gastric bypass surgery (GBS) on periodontal disease and quantify the periodontopathogenic bacteria in patients undergoing this surgery. MATERIAL AND METHODS: This prospective study was composed of 50 patients who underwent bariatric surgery and the data collection was performed in three periods pre-operative, 6 (6M) and 12 months (12 M) postoperative. The oral clinical examination to assess periodontal disease; gingival fluid sample collection for quantification of the periodontopathogenic bacteria Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, and Prevotella intermedia using q-PCR; body mass index (BMI) and for collection of the individual's health-related data from medical files. RESULTS: There was a significant reduction in serum C-reactive protein (CRP) and glucose levels after surgery. The mean probing pocket depth (PPD) and clinical attachment level (CAL) increased significantly in the postoperative period of 6 months (p = 0.001). In the same period, the amount of P. gingivalis increased (p = 0.028) and the other bacteria decreased slightly (p > 0.050). In the presence of P. gingivalis, T. forsythia, T. denticola and P. intermedia, a poor periodontal condition was observed. CONCLUSION: The periodontal disease increased in severity and P. gingivalis increased after GBS. A systemic inflammation resolution due to bariatric surgery in obese subjects does not seem to affect the course of periodontal disease.


Assuntos
Derivação Gástrica/métodos , Índice Periodontal , Adulto , Glicemia/análise , Índice de Massa Corporal , Proteína C-Reativa/análise , Estudos de Coortes , Cálculos Dentários/classificação , Feminino , Seguimentos , Líquido do Sulco Gengival/microbiologia , Humanos , Masculino , Pessoa de Meia-Idade , Perda da Inserção Periodontal/classificação , Perda da Inserção Periodontal/microbiologia , Bolsa Periodontal/classificação , Bolsa Periodontal/microbiologia , Porphyromonas gingivalis/isolamento & purificação , Prevotella intermedia/isolamento & purificação , Estudos Prospectivos , Tannerella forsythia/isolamento & purificação , Treponema denticola/isolamento & purificação , Redução de Peso
8.
Int Dent J ; 64(3): 144-9, 2014 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-24410073

RESUMO

OBJECTIVES: We evaluate oral health conditions before and after bariatric surgery. METHODS: The sample was composed of 59 patients who had undergone Roux-en-Y gastric bypass (RYGB). Salivary flow, periodontal pocket depth and dental wear were evaluated before and after 6 months of surgery. Body mass index (BMI), C-reactive protein (CRP) and glucose levels were obtained from the patient's medical files. A t-test was used for dependent samples. RESULTS: The mean BMI decreased from 49.31 ± 8.76 to 35.52 ± 8.12 kg/m(2) in 6 months after surgery (P < 0.000). Before surgery, 67% of patients had high levels of CRP and 38% higher blood glucose levels and after surgery there were significant reductions in these levels (P < 0.001). Salivary flow ranged from 0.84 to 0.95 ml/min. There was increased prevalence of periodontal pockets (P = 0.022) and mean pocket depth increased to about 0.5 mm (P < 0.001). The percentage of surfaces with dental wear in dentine was significantly higher after bariatric surgery (P = 0.002), while dental wear in enamel decreased (P = 0.019). CONCLUSIONS: Bariatric surgery may improve systemic conditions. However, it had a negative impact on oral health conditions because of an increase in periodontal disease and dental wear.


Assuntos
Derivação Gástrica/métodos , Saúde Bucal , Adulto , Glicemia/análise , Índice de Massa Corporal , Proteína C-Reativa/análise , Estudos de Coortes , Esmalte Dentário/patologia , Dentina/patologia , Complicações do Diabetes/sangue , Feminino , Seguimentos , Humanos , Masculino , Obesidade Mórbida/sangue , Obesidade Mórbida/cirurgia , Perda da Inserção Periodontal/classificação , Índice Periodontal , Bolsa Periodontal/classificação , Saliva/metabolismo , Taxa Secretória/fisiologia , Desgaste dos Dentes/classificação
9.
Surg Obes Relat Dis ; 10(1): 49-54, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24071485

RESUMO

BACKGROUND: Iron deficiency and anemia are changes often associated with obesity. Bariatric surgery is responsible for increasing the iron loss and reducing its absorption. The objective of this study was to evaluate anemia and iron deficiency before and after bariatric surgery and to relate them to possible predisposing factors. METHODS: A retrospective study was conducted on obese patients submitted to open Roux-en-Y gastric bypass, in which clinical and laboratory data were obtained up to 48 months postoperatively. Patients were divided into groups according to the presence or absence of anemia and to the presence or absence of iron deficiency (even without anemia), and all data were compared between these groups. RESULTS: Preoperatively, 21.5% of patients had anemia and 20% had iron deficiency. The number of patients with anemia did not vary through the 4 years of the study, but ferritin levels significantly decreased with time (P<.01). Younger patients and patients with greater weight loss had a higher incidence of anemia. Female gender was a variable associated with a greater incidence of iron deficiency. CONCLUSIONS: Anemia and iron deficiency are frequent in obese patients and must be treated before surgery. Medical and nutritional surveillance is important in the postoperative period of bariatric surgery. Management of each condition must be directed at correcting the 2 major sources of iron deficiency and anemia: food intolerance (mostly meat intolerance) and losses (frequently due to menstruation). These are the factors more related to iron deficient anemia.


Assuntos
Anemia/etiologia , Derivação Gástrica , Deficiências de Ferro , Obesidade Mórbida/cirurgia , Complicações Pós-Operatórias/etiologia , Adulto , Índice de Massa Corporal , Suplementos Nutricionais , Feminino , Compostos Ferrosos/administração & dosagem , Humanos , Masculino , Obesidade Mórbida/complicações , Cuidados Pós-Operatórios , Cuidados Pré-Operatórios , Estudos Retrospectivos , Oligoelementos/administração & dosagem , Redução de Peso/fisiologia
10.
Arq Bras Cir Dig ; 26(2): 124-8, 2013 Jun.
Artigo em Português | MEDLINE | ID: mdl-24000025

RESUMO

BACKGROUND: Bariatric surgery helps significantly in weight loss. Little is known whether the change in body shape and size is enough to meet the expectations created preoperatively. AIM: To evaluate the different perceptions of body size and shape before and after bariatric surgery. METHOD: A total of 423 patients were evaluated by Nine-figure Outline Scale. Of these, 32% were pre-surgery (PreS), 20% were evaluated between 10 and 12 months after surgery (PO-1), 13% between 18 and 24 months (PO-2), 15% between 30 and 36 months (PO-3) and 20% after 42 months of operation (PO-4). Groups were compared using one-way analysis of variance. RESULTS: When choosing figures that represented a man and a woman of normal size, no differences were observed between groups. Regarding the choice of figures representing the own size, differences were observed between groups PreS and all other groups (p<0.001), and PreS chosen larger figures. In choosing figures that represented a size that believed they could achieve, PreS differed from the PO-1, PO-2 and PO-3 (p <0.001), showing a tendency to choose larger silhouettes after surgery. When choosing figures that represented a size that would like to have PO-4 differed from PO-1 and PO-2 (p <0.05), showing that in the PO-4 there was a tendency to choose larger figures. CONCLUSION: The body perception seems to comply with own body size, even after weight loss. As longer postoperative period, the participants were more aware of the real possibilities of weight loss. There were signs of dissatisfaction with the body size and shape, mainly in the PO-1 and PO-2, which can lead to frustration and little use of the benefits of the surgery for health and quality of life.


Assuntos
Cirurgia Bariátrica , Imagem Corporal/psicologia , Obesidade Mórbida/psicologia , Obesidade Mórbida/cirurgia , Feminino , Humanos , Masculino
11.
ABCD (São Paulo, Impr.) ; 26(2): 124-128, abr.-jun. 2013. graf, tab
Artigo em Português | LILACS | ID: lil-684424

RESUMO

RACIONAL: A cirurgia bariátrica favorece significativa perda de peso. Pouco se sabe se a mudança no tamanho e forma corporal é suficiente para suprir as expectativas criadas no pré-operatório. OBJETIVO: Avaliar as diferentes percepções de tamanho e forma corporal antes e após operação bariátrica. MÉTODO: Foram avaliados 423 pacientes utilizando-se a Escala de Desenhos de Silhuetas. Desses, 32% foram avaliados no pré-operatório (PreO), 20% entre 10 e 12 meses após a operação (PO-1), 13% entre 18 e 24 meses (PO-2), 15% entre 30 e 36 meses (PO-3) e 20% a partir de 42 meses da operação (PO-4). Os grupos foram comparados utilizando-se ANOVA (SPSS 17.0). RESULTADOS: Ao escolheram figuras representativas de um homem e de uma mulher de tamanho normal, não se observaram diferenças entre os grupos. Quanto às escolhas de figuras que representavam o próprio tamanho, o grupo PreO diferenciou-se de todos os grupos (p<0,001) escolhendo figuras maiores. Ao escolherem figuras representativas de um tamanho que acreditavam que poderiam alcançar, o grupo PreO se diferenciou de PO-1, PO-2 e PO-3 (p<0,001), mostrando tendência a escolha de figuras de silhuetas maiores depois da operação. Nas escolhas de figuras que representavam um tamanho que gostariam de ter, o grupo PO-4 se diferenciou de PO-1 e PO-2 (p<0,05), mostrando que no PO-4 houve tendência a escolha de figuras maiores. CONCLUSÃO: A percepção corporal parece estar de acordo com o próprio tamanho, inclusive após perda de peso. Quanto maior o tempo pós- operatório, maior a consciência das reais possibilidades de perda de peso. Observaram-se sinais de insatisfação com o tamanho e forma corporal, principalmente no PO-1 e PO-2, o que pode levar à frustração e pouco uso dos benefícios da operação para a saúde e qualidade de vida.


BACKGROUND: Bariatric surgery helps significantly in weight loss. Little is known whether the change in body shape and size is enough to meet the expectations created preoperatively. AIM: To evaluate the different perceptions of body size and shape before and after bariatric surgery. METHOD: A total of 423 patients were evaluated by Nine-figure Outline Scale. Of these, 32% were pre-surgery (PreS), 20% were evaluated between 10 and 12 months after surgery (PO-1), 13% between 18 and 24 months (PO-2), 15% between 30 and 36 months (PO-3) and 20% after 42 months of operation (PO-4). Groups were compared using one-way analysis of variance. RESULTS: When choosing figures that represented a man and a woman of normal size, no differences were observed between groups. Regarding the choice of figures representing the own size, differences were observed between groups PreS and all other groups (p<0.001), and PreS chosen larger figures. In choosing figures that represented a size that believed they could achieve, PreS differed from the PO-1, PO-2 and PO-3 (p <0.001), showing a tendency to choose larger silhouettes after surgery. When choosing figures that represented a size that would like to have PO-4 differed from PO-1 and PO-2 (p <0.05), showing that in the PO-4 there was a tendency to choose larger figures. CONCLUSION: The body perception seems to comply with own body size, even after weight loss. As longer postoperative period, the participants were more aware of the real possibilities of weight loss. There were signs of dissatisfaction with the body size and shape, mainly in the PO-1 and PO-2, which can lead to frustration and little use of the benefits of the surgery for health and quality of life.


Assuntos
Feminino , Humanos , Masculino , Cirurgia Bariátrica , Imagem Corporal/psicologia , Obesidade Mórbida/psicologia , Obesidade Mórbida/cirurgia
12.
Eur J Dent ; 6(2): 191-7, 2012 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-22509123

RESUMO

OBJECTIVES: The aim of this study was to identify the prevalence of dental caries, periodontal diseases and tooth wear in bariatric patients, and relate the oral health conditions to saliva flow. METHODS: Fifty-two patients who had undergone bariatric surgery (Roux-en-Y gastric bypass) and 50 severely obese patients indicated for bariatric surgery were submitted to clinical examinations with regard to dental caries (DMFT index), periodontal condition (CPI index), dental wear (DWI index - Dental wear index) and saliva flow. The data were statistically analyzed by the Student's-t, Mann-Whitney, Spearman Correlation and Chi-square (χ(2)) tests at 5% significance level. RESULTS: The DMFT index was 16.11±5.19 in the surgical group and 16.06±6.29 in the control group (P>.05). The mean CPI was 3.05±0.84 for the operated group and 2.66±1.25 for the obese patients with no significant difference between them (P>.05). There was statistically significant difference between the groups for the presence of periodontal pockets (P=.021). All the patients presented some degree of tooth wear, however, with no significant difference between the two groups (P=.82). The mean saliva flow values of the surgical group and control group were 0.64±0.46 mL/min and 0.66±0.49 mL/min, respectively. There was no significant difference in saliva flow and all oral conditions analyzed (P>.05). CONCLUSION: The prevalence of oral diseases was similar in severely obese patients who were candidates for bariatric surgery and in patients who had been submitted to bariatric surgery. Nevertheless, there was higher prevalence of periodontal pockets in the operated group.

13.
Nutr Metab Insights ; 5: 71-6, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-23882150

RESUMO

OBJECTIVE: The objective of the present study was to identify new risk factors associated with longer hospitalization following bariatric surgery. METHODS: Patient clinical, social, and biochemical data in addition to multidisciplinary team experience were analyzed in a cohort that included all patients undergoing bariatric surgery at our hospital. The primary outcome was length of hospital stay (LOS). Mortality was recorded to validate the obesity surgery mortality risk score (OS-MRS). RESULTS: This study included 299 sequential patients, 41 ± 10 years of age, and BMI of 50 ± 8 kg/m(2) who underwent bariatric surgery. Two thirds (196) of patients were hypertensive, a third (86) were diabetic and a third (91) were current or former smokers. Overall, LOS was 8 ± 5 days. The predictors of a longer LOS were smoking (P < 0.05) and less multidisciplinary team experience (P < 0.05). Looking at only the last three years of data, LOS was 6 ± 5 days, and the predictors of a longer LOS were low educational attainment (P < 0.02) and smoking (P < 0.01) but not team experience. The global mortality was 2.6%, with the OS-MRS identifying a high-risk group. CONCLUSION: Excluding the initial learning phase, longer LOS independent predictors were patient low educational attainment and smoking. These predictors can help guide care to reduce complications.

14.
Nutrition ; 28(4): 391-6, 2012 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-22055480

RESUMO

OBJECTIVE: The objective of this study was to determine whether constant daily vitamin supplementation would be sufficient to prevent possible vitamin deficiencies in obese patients undergoing bariatric surgery. METHODS: The study was conducted on 58 men and women (mean age 41 ± 10 y) who underwent Roux-en-Y gastric bypass RYGB and were assessed preoperatively and at 3, 6, and 12 mo after surgery. During the postoperative period, the patients received a multivitamin-mineral supplement on a daily basis. RESULTS: Serum ß-carotene and vitamin C were lower starting from the third postoperative month and continued to be low after 12 mo, and vitamin A was decreased by the sixth month and increased by 12 mo. Vitamin B12 levels were stable up to 6 mo but were decreased by 12 mo. Folic acid levels increased from the third month and remained higher throughout follow-up. One year after surgery there were 19% and 21% increases in the number of patients with vitamin A and vitamin C deficiency, respectively, and a 4% decreased of patients with folic acid deficiency. CONCLUSION: Weight loss and improvement in patients' general condition followed surgery, but serum levels of some vitamins were decreased despite the use of a vitamin-mineral supplement. These patients need continuous follow-up and individualized prescription of supplementation after the surgical procedure to prevent and treat vitamin deficiencies.


Assuntos
Deficiência de Vitaminas/prevenção & controle , Suplementos Nutricionais , Derivação Gástrica , Obesidade/cirurgia , Complicações Pós-Operatórias/prevenção & controle , Vitaminas/uso terapêutico , Adulto , Deficiência de Vitaminas/epidemiologia , Deficiência de Vitaminas/etiologia , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Obesidade/sangue , Complicações Pós-Operatórias/epidemiologia , Prevalência , Vitaminas/sangue , Vitaminas/farmacologia
16.
Acta Cir Bras ; 26 Suppl 2: 74-8, 2011.
Artigo em Inglês | MEDLINE | ID: mdl-22030819

RESUMO

PURPOSE: To assess in vitro the correlation between the number of neurons and the sensitivity to cholinergic drugs and acetylcholinesterase activity in chagasic patients. METHODS: A 3 x 1 cm strip of the muscle layer of the anterior part of the stomach, always close to the angular incisure, was removed from 10 chronic chagasic patients (6 men) submitted to megaesophagus or megacolon surgery and from 10 non-chagasic patients (4 men) submitted to other types of surgery (control group), aged on average 52.3 and 50.1 years, respectively, for histological and pharmacological studies. The action of cholinergic drugs was investigated in isolated preparations according to the superfusion method of Ferreira and Costa, and acetylcholinesterase activity was determined by the method of Ellman. For neuron count, the strips were cut into 8 µm sections according to the method standardized by Alcântara. RESULTS: There was a difference in number of neurons between the chagasic (5,6) and control (7,3) groups. Acetylcholinesterase activity, in moles of hydrolyzed substrate per minute per gram tissue, was reduced in chagasic patients (4,32) compared to the controls (7,30). No hypersensitivity of the gastric musculature to cholinergic drugs was detected, with a reduced maximum response to carbachol and betanechol in the chagasic group. CONCLUSIONS: The reduction of neurons in the myenteric plexus of the stomach of chronic chagasic patients can be demonstrated even in the absence of clinical chagasic gastropathy. The hypersensitivity of the gastric musculature to cholinergic drugs probably depends on intense denervation. The reduced acetylcholinesterase activity demonstrates the involvement of the cholinergic innervation in the stomach of chronic chagasic patients. There was no correlation between number of neurons, sensitivity to cholinergic drugs and acetylcholinesterase activity in the gastric musculature of chagasic and non-chagasic patients.


Assuntos
Acetilcolinesterase/metabolismo , Doença de Chagas/tratamento farmacológico , Colinérgicos/farmacologia , Músculo Liso/inervação , Plexo Mientérico/patologia , Estômago/inervação , Acetilcolina/farmacologia , Adulto , Carbacol/farmacologia , Estudos de Casos e Controles , Contagem de Células , Doença de Chagas/enzimologia , Agonistas Colinérgicos/farmacologia , Acalasia Esofágica/patologia , Acalasia Esofágica/cirurgia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Músculo Liso/efeitos dos fármacos , Músculo Liso/enzimologia , Neurônios/citologia , Estômago/efeitos dos fármacos , Estômago/enzimologia
17.
Acta Cir Bras ; 26 Suppl 2: 79-83, 2011.
Artigo em Inglês | MEDLINE | ID: mdl-22030820

RESUMO

PURPOSE: To evaluate oral changes, such as dental caries, periodontal disease, dental wear and salivary flow in bariatric patients. Fifty four obese patients who underwent bariatric surgery were studied before (n=54), up after 3 months (n=24) and 6 months (n=16). METHODS: Indices for evaluating oral conditions were: DMFT, CPI, DWI and salivary flow. OIDP questionnaire was used to assess the impact of oral health on quality of life. ANOVA and Spearman correlation were used (p<0.05). RESULTS: DMFT was 17.6 ± 5.7, 18.4 ± 4.1 and 18.3 ± 5.5 (P>0.05), presence of periodontal pockets in 50%, 58% and 50% of patients (p>0.05), tooth wear in dentin present in 81.5%, 87.5% and 87.5% before, 3 and 6 months after surgical treatment respectively. There were differences between the three periods for prevalence and severity of dental wear (p = 0.012). Salivary flow was 0.8 ± 0.5 ml/min before surgery, 0.9 ± 0.5 ml/min for 3 months and 1.1 ± 0.5m/min for 6 months (p>0.05). The impact of oral health on quality of life decreased with time after bariatric surgery (p= 0.029). CONCLUSION: The lifestyle changes after bariatric surgery and these changes may increase the severity of pre-existing dental problems. However, these alterations in oral health did not influence the quality of life.


Assuntos
Cirurgia Bariátrica/efeitos adversos , Saúde Bucal/estatística & dados numéricos , Bolsa Periodontal/etiologia , Qualidade de Vida , Desgaste dos Dentes/etiologia , Xerostomia/etiologia , Adulto , Análise de Variância , Cirurgia Bariátrica/reabilitação , Brasil/epidemiologia , Índice CPO , Feminino , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Bolsa Periodontal/epidemiologia , Período Pós-Operatório , Salivação/fisiologia , Fatores de Tempo , Desgaste dos Dentes/epidemiologia , Xerostomia/epidemiologia
18.
Acta Cir Bras ; 26 Suppl 2: 84-91, 2011.
Artigo em Inglês | MEDLINE | ID: mdl-22030821

RESUMO

PURPOSE: To evaluate the morphological aspects of the behavior of 4 types of latex biomembranes implanted in preperitoneal videolaparoscopic inguinoplasty. METHODS: Sixteen inguinoplasties were performed in 12 dogs: group 1 received an impermeable latex biomembrane in the right inguinal region and a prolene prosthesis, as control, in the contralateral inguinal region; groups 2, 3 and 4 received latex biomembranes respectively containing impermeable polyamide, 1-mm thick porous polyamide and 0.5-mm thick porous polyamide. Macro- and microscopic evaluations of the inguinal region and of the removed implants were made on the 7th, 14th, 21st and 28th days in group 1 and on the 28th postoperative day in the other groups. RESULTS: We observed absence of hematoma, seroma and infection; presence of tortuosities; induction of vascular neoformation, inflammatory reaction and collagen deposition, and full encystment of the latex biomembranes, except that with fine porous polyamide, which was partially incorporated, with the formation of microcysts. No latex biomembrane induced fibrosis as observed in the prolene control group. CONCLUSIONS: The biomembranes maintain induction of the healing process without fibrosis, are fully encysted and, except for the one with fine porous polyamide, are not incorporated into adjacent tissues. The latex biomembrane, with or without polyamide, is not recommended as a separate material for preperitoneal inguinoplasty.


Assuntos
Bioprótese , Canal Inguinal/cirurgia , Látex/uso terapêutico , Membranas Artificiais , Animais , Materiais Biocompatíveis , Cães , Hérnia Inguinal/cirurgia , Masculino , Teste de Materiais , Modelos Animais , Período Pós-Operatório , Desenho de Prótese , Implantação de Prótese/métodos , Cirurgia Vídeoassistida , Cicatrização
19.
ABCD (São Paulo, Impr.) ; 24(3): 226-231, jul.-set. 2011. tab
Artigo em Português | LILACS-Express | LILACS | ID: lil-608391

RESUMO

RACIONAL: Operações bariátricas têm sido consideradas alternativa para o tratamento de obesidade mórbida. Alguns eventos adversos que as pessoas experimentam após o tratamento frequentemente são consequência da falta de conhecimento consistente associada a fatores psicossociais que estão relacionadas ao status pré-operatório dos pacientes. OBJETIVO: Avaliar as variáveis ?psicossociais de 414 candidatos ? cirurgia bari?trica do Hospital de Cl?nicas da Faculdade de Medicina da Universidade de S?o Paulo, Ribeir?o Preto, SP, Brasil. psicossociais de 414 candidatos à cirurgia bariátrica do Hospital de Clínicas da Faculdade de Medicina da Universidade de São Paulo, Ribeirão Preto, SP, Brasil. MÉTODOS: Foram utilizados entrevista semi-estruturada, Inventário de Depressão de Beck (BDI), Inventário de Ansiedade de Beck (BAI) e Binge Eating Scale (BES). RESULTADOS: IMC foi maior entre os pacientes que não tinham emprego (p = 0,019), do sexo feminino, os que tinham um parceiro e os pacientes com IMC <50 kg / m², todos eles desejando ter peso menor (p<0,001). Escores do BAI foram maiores entre os pacientes que não tinham emprego (p <0,05) e maior naqueles com IMC> 50 kg / m² (p <0,05). BDI foram mais altos entre as mulheres (p <0,05) e menores entre aqueles que tinham um emprego (p <0,01). Nenhuma diferença no BES foi encontrada. CONCLUSÕES: Os dados sugerem que as mulheres apresentaram indicadores mais elevados de ansiedade e depressão, sugerindo que elas tinham funcionamento psicológico mais frágil com dificuldades em lidar com a angústia. Auto-percepção, assim como competências e habilidades, podem refletir aspectos internos da personalidade do indivíduo. Pacientes que tiveram um emprego antes da operação parecia ter mais recursos emocionais. Assim, eles podiam sentir menos sofrimento, porque o emprego podia protegê-los. Mulheres e aqueles que não tinham emprego eram mais propensos a apresentar sintomas de depressão. Além disso, pacientes que não tinham emprego e aqueles com IMC> 50 kg / m² foram mais propensos a apresentar sintomas de ansiedade.


BACKGROUND: Bariatric surgeries have been considered an alternative for treatment of morbid obesity. Some adverse events that people experience after the treatment frequently are the consequence of the lack of consistent knowledge associated with psychosocial factors that are related to the pre-surgery status of the patients. AIM: To evaluate psychosocial variables of 414 candidates for bariatric surgery from Clinical Hospital of Medical School at University of São Paulo, Ribeirão Preto, SP, Brazil. METHODS: Semi-structured interview, Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI) and Binge Eating Scale (BES) were used. RESULTS: BMI was higher among patients who had no employment (p = 0.019). Female, patients who had a partner and patients with a BMI < 50 kg/m², all of them desired have a lower weight (p < 0.001). BAI scores were higher among patients who had no employment (p < 0.05) and higher among those with a BMI > 50 kg/m² (p < 0.05). BDI scores were higher among women (p < 0.05) and lower among those who had an employment (p < 0.01). No difference in BES was found. CONCLUSIONS: The data suggest that women showed higher indicators of anxiety and depression, suggesting that they had a more fragile psychological functioning with difficulties in coping with distress. Self-perception as well as skills and abilities, may reflect internal aspects of individual's personality. Patients who had an employment before surgery seemed have more emotional resources. So, they may feel less distress because the employment may protect them. Women and those who did not have an employment were more likely to experience depression symptoms. Furthermore, patients who did not have an employment and those with BMI> 50 kg / m² were more likely to experience anxiety symptoms.

20.
J Laparoendosc Adv Surg Tech A ; 21(7): 579-82, 2011 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-21657939

RESUMO

AIMS: Surgical staple line dehiscence usually leads to severe complications. Several techniques and materials have been used to reinforce this stapling and thus reduce the related complications. The objective was to compare safety of two types of anastomotic reinforcement in open gastric bypass. METHODS: A prospective, randomized study comparing an extraluminal suture, fibrin glue, and a nonpermanent buttressing material, Seamguard®, for staple line reinforcement. Fibrin glue was excluded from the study and analysis after two leaks, requiring surgical reintervention, antibiotic therapy, and prolonged patient hospitalization. RESULTS: Twenty patients were assigned to the suture and Seamguard reinforcement groups. The groups were similar in terms of preoperative characteristics. No staple line dehiscence occurred in the two groups, whereas two cases of dehiscence occurred in the fibrin glue group. No mortality occurred and surgical time was statistically similar for both techniques. Seamguard made the surgery more expensive. CONCLUSION: In our service, staple line reinforcement in open bariatric surgery with oversewing or Seamguard was considered to be safe. Seamguard application was considered to be easier than oversewing, but more expensive.


Assuntos
Implantes Absorvíveis , Adesivo Tecidual de Fibrina , Derivação Gástrica/métodos , Grampeamento Cirúrgico/métodos , Adesivos Teciduais , Adulto , Feminino , Humanos , Masculino , Estudos Prospectivos
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